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I would love to see others giving their small biz tips. With that goal, I'm going to start sharing my experiences.
Background, I run a small company that works all over, sometimes out of country, but mostly in the midwest. We gather data for our clients which we transfer over the web via a secure server. Transferring the data is not our main business, but an integral task.
In the early days we emailed it, but emailing 10 megs, then 20 megs, then 50 megs of data became a pain, especially when you are doing it from a slow connection in Carroll, Iowa. So we came up with this secure server idea, using repository version control software to keep track of changes and ensure the data is properly backed up and complete. It works like AWESOME.